The evolution and mechanism of GPCR proton sensing

Of the 800 G protein–coupled receptors (GPCRs) in humans, only three (GPR4, GPR65, and GPR68) regulate signaling in acidified microenvironments by sensing protons (H+). How these receptors have uniquely obtained this ability is unknown. Here, we show these receptors evolved the capability to sense H...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100167, Article 100167
Hauptverfasser:	Rowe, Jacob B., Kapolka, Nicholas J., Taghon, Geoffrey J., Morgan, William M., Isom, Daniel G.
Format:	Artikel
Sprache:	eng
Schlagworte:	allosteric modulator coincidence detection evolution G protein–coupled receptor proton proton sensing sodium
Online-Zugang:	Volltext
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