Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12

Cytotoxic molecules can kill cancer cells by disrupting critical cellular processes or by inducing novel activities. 6-(4-(Diethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one (DNMDP) is a small molecule that kills cancer cells by generation of novel activity. DNMDP induces complex f...

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Veröffentlicht in:	The Journal of biological chemistry 2020-03, Vol.295 (11), p.3431-3446
Hauptverfasser:	Wu, Xiaoyun, Schnitzler, Gavin R., Gao, Galen F., Diamond, Brett, Baker, Andrew R., Kaplan, Bethany, Williamson, Kaylyn, Westlake, Lindsay, Lorrey, Selena, Lewis, Timothy A., Garvie, Colin W., Lange, Martin, Hayat, Sikander, Seidel, Henrik, Doench, John, Cherniack, Andrew D., Kopitz, Charlotte, Meyerson, Matthew, Greulich, Heidi
Format:	Artikel
Sprache:	eng
Schlagworte:	AIP Base Sequence Biochemistry & Molecular Biology biomarker Biomarkers, Tumor - metabolism cancer biology cancer therapy Catalytic Domain Cell Biology cell death Cell Death - drug effects Cell Line, Tumor chaperone CRISPR-Cas Systems - genetics Cyclic Nucleotide Phosphodiesterases, Type 3 - chemistry Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism DNMDP Frameshift Mutation - genetics Genome Heterozygote Humans Intracellular Signaling Peptides and Proteins - metabolism Life Sciences & Biomedicine Neoplasms - pathology PDE3A PDE3B phosphodiesterases Protein Binding - drug effects protein-protein interaction Pyridazines - pharmacology Science & Technology SLFN12
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