Structures of Human Host Defense Cathelicidin LL-37 and Its Smallest Antimicrobial Peptide KR-12 in Lipid Micelles

As a key component of the innate immunity system, human cathelicidin LL-37 plays an essential role in protecting humans against infectious diseases. To elucidate the structural basis for its targeting bacterial membrane, we have determined the high quality structure of 13C,15N-labeled LL-37 by three...

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Veröffentlicht in:	The Journal of biological chemistry 2008-11, Vol.283 (47), p.32637-32643
1. Verfasser:	Wang, Guangshun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Antimicrobial Cationic Peptides - physiology Bacteria - metabolism Bacterial Proteins - metabolism Cathelicidins - chemistry Humans Lipids - chemistry Micelles Molecular Sequence Data Peptide Fragments - chemistry Phenylalanine - chemistry Phosphatidylglycerols - chemistry Sequence Homology, Amino Acid Sodium Dodecyl Sulfate - chemistry
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