Structural Basis for the Inhibition Mechanism of Human Cystathionine γ-Lyase, an Enzyme Responsible for the Production of H2S

Impairment of the formation or action of hydrogen sulfide (H2S), an endogenous gasotransmitter, is associated with various diseases, such as hypertension, diabetes mellitus, septic and hemorrhagic shock, and pancreatitis. Cystathionine β-synthase and cystathionine γ-lyase (CSE) are two pyridoxal-5′-...

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Veröffentlicht in:	The Journal of biological chemistry 2009-01, Vol.284 (5), p.3076-3085
Hauptverfasser:	Sun, Qingxiang, Collins, Ruairi, Huang, Shufen, Holmberg-Schiavone, Lovisa, Anand, Ganesh S., Tan, Choon-Hong, van-den-Berg, Susanne, Deng, Lih-Wen, Moore, Philip K., Karlberg, Tobias, Sivaraman, J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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