Modulation of Double-stranded RNA Recognition by the N-terminal Histidine-rich Region of the Human Toll-like Receptor 3

Toll-like receptors (TLRs) are an essential component of the innate immune response to microbial pathogens. TLR3 is localized in intracellular compartments, such as endosomes, and initiates signals in response to virus-derived double-stranded RNA (dsRNA). The TLR3 ectodomain (ECD), which is implicat...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2008-08, Vol.283 (33), p.22787-22794
Hauptverfasser:	Fukuda, Kotaro, Watanabe, Tomoya, Tokisue, Takashi, Tsujita, Tadayuki, Nishikawa, Satoshi, Hasegawa, Tsunemi, Seya, Tsukasa, Matsumoto, Misako
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites Cell Line Histidine Humans Kidney - embryology Kinetics Plasmids RNA - chemistry RNA - metabolism RNA, Small Interfering - genetics Toll-Like Receptor 3 - chemistry Toll-Like Receptor 3 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!