Functional Chimeras of the Phosphodiesterase 5 and 10 Tandem GAF Domains

The tandem GAF domain of hPDE10A uses cAMP as an allosteric ligand (Gross-Langenhoff, M., Hofbauer, K., Weber, J., Schultz, A., and Schultz, J. E. (2006) J. Biol. Chem. 281, 2841–2846). We used a two-pronged approach to study how discrimination of ligand is achieved in human (h)PDE10A and how domain...

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Veröffentlicht in:	The Journal of biological chemistry 2008-09, Vol.283 (37), p.25164-25170
Hauptverfasser:	Hofbauer, Karina, Schultz, Anita, Schultz, Joachim E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Crystallography, X-Ray Cyclic AMP - chemistry Cyclic Nucleotide Phosphodiesterases, Type 5 - chemistry Humans Models, Biological Molecular Sequence Data Phosphoric Diester Hydrolases - chemistry Point Mutation Protein Binding Protein Structure, Tertiary Recombinant Fusion Proteins - chemistry Recombinant Proteins - chemistry Sequence Homology, Amino Acid Signal Transduction
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