Probing Structure-Function Relationships and Gating Mechanisms in the CorA Mg2+ Transport System

Recent crystal structures of the CorA Mg2+ transport protein from Thermotoga maritima (TmCorA) revealed an unusually long ion pore putatively gated by hydrophobic residues near the intracellular end and by universally conserved asparagine residues at the periplasmic entrance. A conformational change...

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Veröffentlicht in:	The Journal of biological chemistry 2008-04, Vol.283 (17), p.11721-11733
Hauptverfasser:	Payandeh, Jian, Li, Canhui, Ramjeesingh, Mohabir, Poduch, Ewa, Bear, Christine E., Pai, Emil F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Asparagine - chemistry Cation Transport Proteins - chemistry Cation Transport Proteins - metabolism Cations Chromatography, Gel Dose-Response Relationship, Drug Genetic Complementation Test Ions Magnesium - chemistry Magnesium - metabolism Models, Biological Molecular Conformation Protein Engineering - methods Protein Folding Protein Structure, Secondary Structure-Activity Relationship Thermotoga maritima - metabolism
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