The Direct Involvement of SirT1 in Insulin-induced Insulin Receptor Substrate-2 Tyrosine Phosphorylation

NAD+-dependent Sir2 family deacetylases and insulin signaling pathway are both conserved across species to regulate aging process. The interplay between these two genetic programs is investigated in this study. Protein deacetylase activity of SirT1, the mammalian homologue of Sir2, was suppressed th...

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Veröffentlicht in:	The Journal of biological chemistry 2007-11, Vol.282 (47), p.34356-34364
1. Verfasser:	Zhang, Jiandi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Amino Acid Substitution Animals Cell Line Cellular Senescence - drug effects Cellular Senescence - physiology Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Humans Hypoglycemic Agents - metabolism Hypoglycemic Agents - pharmacology Insulin - metabolism Insulin - pharmacology Insulin Receptor Substrate Proteins Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mutation Niacinamide - pharmacology Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation - drug effects Rats RNA Interference Signal Transduction - drug effects Signal Transduction - physiology Sirtuin 1 Sirtuins - genetics Sirtuins - metabolism Vitamin B Complex - pharmacology
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