Identification of a Novel Prostaglandin Reductase Reveals the Involvement of Prostaglandin E2 Catabolism in Regulation of Peroxisome Proliferator-activated Receptor γ Activation

This report identifies a novel gene encoding 15-oxoprostaglandin-Δ13-reductase (PGR-2), which catalyzes the reaction converting 15-keto-PGE2 to 13,14-dihydro-15-keto-PGE2. The expression of PGR-2 is up-regulated in the late phase of 3T3-L1 adipocyte differentiation and predominantly distributed in a...

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Veröffentlicht in:	The Journal of biological chemistry 2007-06, Vol.282 (25), p.18162-18172
Hauptverfasser:	Chou, Wen-Ling, Chuang, Lee-Ming, Chou, Chi-Chi, Wang, Andrew H.-J., Lawson, John A., FitzGerald, Garret A., Chang, Zee-Fen
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Oxoprostaglandin 13-Reductase - genetics 15-Oxoprostaglandin 13-Reductase - physiology 3T3-L1 Cells Adipocytes - cytology Adipocytes - metabolism Amino Acid Sequence Animals Cell Differentiation Dinoprostone - metabolism Dose-Response Relationship, Drug Fibroblasts - metabolism Humans Mice Molecular Sequence Data Oxygen - metabolism PPAR gamma - metabolism Sequence Homology, Amino Acid
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