Ca2+/Calmodulin Directly Interacts with the Pleckstrin Homology Domain of AKT1

AKT kinase, also known as protein kinase B, is a key regulator of cell growth, proliferation, and metabolism. The activation of the AKT signaling pathway is one of the most frequent molecular alterations in a wide variety of human cancers. Dickson and coworkers recently observed that Ca2+·calmodulin...

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Veröffentlicht in:The Journal of biological chemistry 2007-08, Vol.282 (34), p.25131-25140
Hauptverfasser: Dong, Biao, Valencia, C. Alexander, Liu, Rihe
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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