Regulation of Secreted Frizzled-related Protein-1 by Heparin

Secreted Frizzled-related protein-1 (sFRP-1) belongs to a class of extracellular antagonists that modulate Wnt signaling pathways by preventing ligand-receptor interactions among Wnts and Frizzled membrane receptor complexes. sFRP-1 and Wnts are heparin-binding proteins, and their interaction can be...

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Veröffentlicht in:	The Journal of biological chemistry 2007-07, Vol.282 (28), p.20523-20533
Hauptverfasser:	Zhong, Xiaotian, Desilva, Thamara, Lin, Laura, Bodine, Peter, Bhat, Ramesh A., Presman, Eleonora, Pocas, Jennifer, Stahl, Mark, Kriz, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - pharmacology Cell Line Fibroblast Growth Factor 2 - metabolism Heparin - pharmacology Humans Intracellular Signaling Peptides and Proteins Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Protein Processing, Post-Translational - drug effects Protein Processing, Post-Translational - physiology Proteins - genetics Proteins - metabolism Proteins - pharmacology Receptor, Fibroblast Growth Factor, Type 1 - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Signal Transduction - drug effects Signal Transduction - physiology Wnt Proteins - metabolism
Online-Zugang:	Volltext
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