Clioquinol, a Cu(II)/Zn(II) Chelator, Inhibits Both Ubiquitination and Asparagine Hydroxylation of Hypoxia-inducible Factor-1α, Leading to Expression of Vascular Endothelial Growth Factor and Erythropoietin in Normoxic Cells

We found that the Cu(II) and Zn(II)-specific chelator Clioquinol (10–50 μm) increased functional hypoxia-inducible factor 1α (HIF-1α) protein, leading to increased expression of its target genes, vascular endothelial growth factors and erythropoietin, in SH-SY5Y cells and HepG2 cells. Clioquinol inh...

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Veröffentlicht in:	The Journal of biological chemistry 2006-11, Vol.281 (45), p.34056-34063
Hauptverfasser:	Choi, Su Mi, Choi, Kyung-Ok, Park, Young-Kwon, Cho, Hyunju, Yang, Eun Gyeong, Park, Hyunsung
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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