Fine Tuning PDK1 Activity by Phosphorylation at Ser163

3-Phosphoinositide-dependent protein kinase-1 (PDK1) mediates phosphorylation and activation of members of the AGC protein kinase family and plays an essential role in insulin signaling and action. However, whether and how PDK1 activity is regulated in cells remains largely uncharacterized. In the p...

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Veröffentlicht in:	The Journal of biological chemistry 2006-08, Vol.281 (31), p.21588-21593
Hauptverfasser:	Riojas, Ramon A., Kikani, Chintan K., Wang, Changhua, Mao, Xuming, Zhou, Lijun, Langlais, Paul R., Hu, Derong, Roberts, James L., Dong, Lily Q., Liu, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Phosphoinositide-Dependent Protein Kinases Amino Acid Substitution Animals Binding Sites Cell Line Humans Hydrogen Bonding Insulin - pharmacology Mice Models, Molecular Phosphorylation Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - metabolism Sequence Alignment Serine - metabolism Transfection
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