Inhibition of S/G2 Phase CDK4 Reduces Mitotic Fidelity

Cyclin-dependent kinase 4 (CDK4)/cyclin D has a key role in regulating progression through late G1 into S phase of the cell cycle. CDK4-cyclin D complexes then persist through the latter phases of the cell cycle, although little is known about their potential roles. We have developed small molecule...

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Veröffentlicht in:	The Journal of biological chemistry 2006-04, Vol.281 (15), p.9987-9995
Hauptverfasser:	Burgess, Andrew, Wigan, Matthew, Giles, Nichole, DePinto, Wanda, Gillespie, Paul, Stevens, Frankie, Gabrielli, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caffeine - pharmacology Cell Cycle Cell Cycle Proteins - metabolism Cell Line Cell Proliferation Cyclin-Dependent Kinase 4 - chemistry Cyclin-Dependent Kinase 4 - metabolism DNA, Complementary - metabolism Enzyme Inhibitors - pharmacology G1 Phase G2 Phase HeLa Cells Humans Imidazoles - pharmacology Inhibitor of Apoptosis Proteins Inhibitory Concentration 50 Kinetics Microtubule-Associated Proteins - metabolism Mitosis Models, Chemical Neoplasm Proteins - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phenotype Phosphorylation Protein Binding Proto-Oncogene Proteins c-akt - metabolism Pyridines - pharmacology Retinoblastoma Protein - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry RNA, Small Interfering - metabolism S Phase Survivin Time Factors
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