Diallyl Trisulfide Suppresses the Proliferation and Induces Apoptosis of Human Colon Cancer Cells through Oxidative Modification of β-Tubulin

Allyl sulfides are characteristic flavor components obtained from garlic. These sulfides are thought to be responsible for their epidemiologically proven anticancer effect on garlic eaters. This study was aimed at clarifying the molecular basis of this anticancer effect of garlic by using human colo...

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Veröffentlicht in:	The Journal of biological chemistry 2005-12, Vol.280 (50), p.41487-41493
Hauptverfasser:	Hosono, Takashi, Fukao, Tomomi, Ogihara, Jun, Ito, Yoshimasa, Shiba, Hajime, Seki, Taiichiro, Ariga, Toyohiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Allyl Compounds - chemistry Allyl Compounds - pharmacology Animals Antineoplastic Agents - pharmacology Apoptosis Blotting, Western Cell Cycle Cell Line, Tumor Cell Proliferation Cell Separation Cell-Free System Chromatography, Liquid Colonic Neoplasms - metabolism Cyclin B - metabolism Cyclin B1 Cysteine - analogs & derivatives Cysteine - chemistry Cytoplasm - metabolism Disulfides - chemistry DNA - chemistry Flow Cytometry Fluorescent Antibody Technique, Indirect Garlic Humans Inhibitory Concentration 50 Mice Mice, Nude Microtubules - metabolism Microtubules - ultrastructure Neoplasm Transplantation Oxidative Stress Oxygen - chemistry Peptides - chemistry Protein Binding Sulfides - chemistry Sulfides - pharmacology Time Factors Tubulin - chemistry
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