Molecular and Pharmacological Properties of a Potent and Selective Novel Nonsteroidal Progesterone Receptor Agonist Tanaproget

Progesterone receptor (PR) agonists have several important applications in women's health, such as in oral contraception and post-menopausal hormone therapy. Currently, all PR agonists used clinically are steroids. Because of their interactions with other steroid receptors, steroid-metabolizing...

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Veröffentlicht in:	The Journal of biological chemistry 2005-08, Vol.280 (31), p.28468-28475
Hauptverfasser:	Zhang, Zhiming, Olland, Andrea M, Zhu, Yuan, Cohen, Jeff, Berrodin, Tom, Chippari, Susan, Appavu, Chandrasekaran, Li, Shen, Wilhem, James, Chopra, Raj, Fensome, Andrew, Zhang, Puwen, Wrobel, Jay, Unwalla, Rayomand J, Lyttle, C Richard, Winneker, Richard C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Amino Acid Substitution Benzoxazines - agonists Binding Sites Breast Neoplasms Cell Line, Tumor Humans Ligands Mutagenesis, Site-Directed Promegestone - analogs & derivatives Promegestone - pharmacology Pyrroles - agonists Receptors, Progesterone - agonists Receptors, Progesterone - chemistry Receptors, Progesterone - genetics Recombinant Proteins - agonists X-Ray Diffraction
Online-Zugang:	Volltext
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