The Selectivity Filter of the Cation Channel TRPM4

Transient receptor potential channel melastatin subfamily (TRPM) 4 and its close homologue, TRPM5, are the only two members of the large transient receptor potential superfamily of cation channels that are impermeable to Ca 2+ . In this study, we located the TRPM4 selectivity filter and investigated...

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Veröffentlicht in:	The Journal of biological chemistry 2005-06, Vol.280 (24), p.22899-22906
Hauptverfasser:	Nilius, Bernd, Prenen, Jean, Janssens, Annelies, Owsianik, Grzegorz, Wang, Chunbo, Zhu, Michael X, Voets, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - chemistry Amino Acid Sequence Biotinylation Calcium - chemistry Calcium - metabolism Calcium Channels - chemistry Cation Transport Proteins - chemistry Cations Cell Line Electrophysiology Gene Deletion Genes, Dominant Glutamic Acid - chemistry Green Fluorescent Proteins - metabolism Humans Inhibitory Concentration 50 Magnesium - chemistry Membrane Proteins - chemistry Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Mutation Phenotype Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Sequence Homology, Amino Acid Time Factors TRPM Cation Channels
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