Role of Phospholipase C-ζ Domains in Ca2+-dependent Phosphatidylinositol 4,5-Bisphosphate Hydrolysis and Cytoplasmic Ca2+ Oscillations

The sperm-specific phospholipase C-ζ (PLCζ) elicits fertilization-like Ca2+ oscillations and activation of embryo development when microinjected into mammalian eggs (Saunders, C. M., Larman, M. G., Parrington, J., Cox, L. J., Royse, J., Blayney, L. M., Swann, K., and Lai, F. A. (2002) Development (C...

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Veröffentlicht in:	The Journal of biological chemistry 2005-09, Vol.280 (35), p.31011-31018
Hauptverfasser:	Nomikos, Michail, Blayney, Lynda M., Larman, Mark G., Campbell, Karen, Rossbach, Andreas, Saunders, Christopher M., Swann, Karl, Lai, F. Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Cytoplasm - chemistry Cytoplasm - metabolism Female Humans Hydrogen-Ion Concentration Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - metabolism Mice Microinjections Molecular Sequence Data Oocytes - cytology Oocytes - physiology Phosphatidylinositol 4,5-Diphosphate - chemistry Phosphatidylinositol 4,5-Diphosphate - metabolism Phosphoinositide Phospholipase C Phospholipase C delta Protein Conformation Rats Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Deletion Type C Phospholipases - chemistry Type C Phospholipases - genetics Type C Phospholipases - metabolism
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