Determining the Environment of the Ligand Binding Pocket of the Human Angiotensin II Type I (hAT1) Receptor Using the Methionine Proximity Assay

The peptide hormone angiotensin II (AngII) binds to the AT1 (angiotensin type 1) receptor within the transmembrane domains in an extended conformation, and its C-terminal residue interacts with transmembrane domain VII at Phe-293/Asn-294. The molecular environment of this binding pocket remains to b...

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Veröffentlicht in:	The Journal of biological chemistry 2005-07, Vol.280 (29), p.27121-27129
Hauptverfasser:	Clément, Martin, Martin, Stéphane S., Beaulieu, Marie-Ève, Chamberland, Caroline, Lavigne, Pierre, Leduc, Richard, Guillemette, Gaétan, Escher, Emanuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Angiotensin II - metabolism Benzophenones Binding Sites Humans Ligands Methionine - genetics Models, Molecular Molecular Probe Techniques Mutagenesis, Site-Directed Protein Binding Protein Interaction Mapping - methods Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism
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