Opposing Effects of Protein Kinase Cα and Protein Kinase Cϵ on Collagen Expression by Human Lung Fibroblasts Are Mediated via MEK/ERK and Caveolin-1 Signaling

The roles of MEK, ERK, the ϵ and α isoforms of protein kinase C (PKC), and caveolin-1 in regulating collagen expression were studied in normal lung fibroblasts. Knocking down caveolin-1 gave particularly striking results. A 70% decrease caused a 5-fold increase in MEK/ERK activation and collagen exp...

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Veröffentlicht in:	The Journal of biological chemistry 2005-04, Vol.280 (14), p.13879-13887
Hauptverfasser:	Tourkina, Elena, Gooz, Pal, Pannu, Jaspreet, Bonner, Michael, Scholz, Dimitri, Hacker, Sharon, Silver, Richard M., Trojanowska, Maria, Hoffman, Stanley
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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