A Novel Caspase-2 Complex Containing TRAF2 and RIP1

The enzymatic activity of caspases is implicated in the execution of apoptosis and inflammation. Here we demonstrate a novel nonenzymatic function for caspase-2 other than its reported proteolytic role in apoptosis. Caspase-2, unlike caspase-3, -6, -7, -9, -11, -12, and -14, is a potent inducer of N...

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Veröffentlicht in:	The Journal of biological chemistry 2005-02, Vol.280 (8), p.6923-6932
Hauptverfasser:	Lamkanfi, Mohamed, D'hondt, Kathleen, Vande Walle, Lieselotte, van Gurp, Marjan, Denecker, Geertrui, Demeulemeester, Jill, Kalai, Michael, Declercq, Wim, Saelens, Xavier, Vandenabeele, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caspase 2 Caspases - genetics Caspases - metabolism Caspases - physiology Cell Line GTPase-Activating Proteins - metabolism Humans Mice Multiprotein Complexes Mutagenesis, Site-Directed NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Protein Structure, Tertiary TNF Receptor-Associated Factor 1 - metabolism TNF Receptor-Associated Factor 2 - metabolism Transfection
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