Distinct Domains Control the Addressing and the Insertion of Bax into Mitochondria

The translocation of Bax from the cytosol into the mitochondrial outer membrane is a central event during apoptosis. We report that beyond the addressing step, which involves its first α-helix (hα1), the helices α5 and α6 (hα5α6) are responsible for the insertion of Bax into mitochondrial outer memb...

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Veröffentlicht in:	The Journal of biological chemistry 2005-03, Vol.280 (11), p.10587-10598
Hauptverfasser:	Cartron, Pierre-François, Arokium, Hubert, Oliver, Lisa, Meflah, Khaled, Manon, Stephen, Vallette, François M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoptosis Aspartic Acid - chemistry Base Sequence bcl-2-Associated X Protein Cell-Free System Cytosol - metabolism Electrophoresis, Polyacrylamide Gel Immunoprecipitation Lipid Bilayers Liver - metabolism Lysine - chemistry Microscopy, Confocal Mitochondria - metabolism Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Mutation Plasmids - metabolism Proline - chemistry Protein Conformation Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Protein Transport Proto-Oncogene Proteins c-bcl-2 - chemistry Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Static Electricity Subcellular Fractions - metabolism Transfection Transgenes Two-Hybrid System Techniques
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