Low Density Lipoprotein Receptor-related Protein Mediates Endocytic Clearance of Pro-MMP-2·TIMP-2 Complex through a Thrombospondin-independent Mechanism

The low density lipoprotein receptor-related protein (LRP) mediates the endocytic clearance of various proteinases and proteinase·inhibitor complexes, including thrombospondin (TSP)-dependent endocytosis of matrix metalloproteinase (MMP)-2 (or gelatinase A), a key effector of extracellular matrix re...

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Veröffentlicht in:The Journal of biological chemistry 2004-12, Vol.279 (52), p.54944-54951
Hauptverfasser: Emonard, Hervé, Bellon, Georges, Troeberg, Linda, Berton, Alix, Robinet, Arnaud, Henriet, Patrick, Marbaix, Etienne, Kirkegaard, Kirstine, Patthy, László, Eeckhout, Yves, Nagase, Hideaki, Hornebeck, William, Courtoy, Pierre J.
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Sprache:eng
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