Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations
Mutations in the tau gene are known to cosegregate with the disease in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). However, the molecular mechanism by which these mutations might lead to the disease is not understood. Here, we show that four of the FTDP-17 tau mutati...
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Veröffentlicht in: | The Journal of biological chemistry 2004-08, Vol.279 (33), p.34873-34881 |
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Format: | Artikel |
Sprache: | eng |
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