Phosphorylation of Threonine 290 in the Activation Loop of Tpl2/Cot Is Necessary but Not Sufficient for Kinase Activity

Cot/Tpl2/MAP3K8 is a serine/threonine kinase known to activate the ERK, p38, and JNK kinase pathways. Studies of Tpl2 knock-out mice reveal a clear defect in tumor necrosis factor-Î± production, although very little detail is known about its regulation and the signaling events involved. In the prese...

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Veröffentlicht in:	The Journal of biological chemistry 2004-12, Vol.279 (50), p.52117-52123
Hauptverfasser:	Luciano, Brenda S, Hsu, Sang, Channavajhala, Padma L, Lin, Lih-Ling, Cuozzo, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals Base Sequence Benzoquinones Cell Line DNA - genetics Enzyme Activation Humans In Vitro Techniques Lactams, Macrocyclic Lipopolysaccharides - pharmacology MAP Kinase Kinase Kinases - antagonists & inhibitors MAP Kinase Kinase Kinases - chemistry MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism MAP Kinase Signaling System Mice Molecular Sequence Data Mutagenesis, Site-Directed NF-kappa B - metabolism Phosphorylation Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Quinones - pharmacology Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Rifabutin - analogs & derivatives Threonine - chemistry Transfection
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