Identification and Characterization of a Cell-Surface Receptor, P2Y15, for AMP and Adenosine

AMP and adenosine are found in all cell types and can be released by cells or created extracellularly from the breakdown of ATP and ADP. We have identified an orphan G protein-coupled receptor with homology to the P2Y family of nucleotide receptors that can respond to both AMP and adenosine. Based o...

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Veröffentlicht in:	The Journal of biological chemistry 2004-05, Vol.279 (19), p.19790-19799
Hauptverfasser:	Inbe, Hisayo, Watanabe, Shinichi, Miyawaki, Miwa, Tanabe, Eri, Encinas, Jeffrey A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - chemistry Adenosine Monophosphate - chemistry Amino Acid Sequence Animals Calcium - metabolism Cell Line Cell Line, Tumor Cloning, Molecular Cyclic AMP - chemistry Cyclic AMP - metabolism DNA, Complementary - metabolism Dose-Response Relationship, Drug GTP-Binding Proteins - metabolism Humans Kinetics Ligands Mice Molecular Sequence Data Phosphorylation Phylogeny Protein Binding Rats Receptors, Cell Surface - chemistry Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - physiology Receptors, Purinergic P1 - chemistry Receptors, Purinergic P2 - chemistry Receptors, Purinergic P2 - physiology Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry Sequence Homology, Amino Acid Signal Transduction Theophylline - chemistry Time Factors Tissue Distribution
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