Furin Inhibition by Compounds of Copper and Zinc

Furin, a human subtilisin-related proprotein convertase (SPC), is emerging as an important pharmaceutical target because it processes vital proteins of many aggressive pathogens. Furin inhibitors reported as yet are peptide derivatives and proteins, with the exception of andrographolides, which are...

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Veröffentlicht in:	The Journal of biological chemistry 2004-08, Vol.279 (35), p.36219-36227
Hauptverfasser:	Podsiadlo, Paul, Komiyama, Tomoko, Fuller, Robert S, Blum, Ofer
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Catalysis Chlorides - pharmacology Copper - chemistry Copper - pharmacology DNA Mutational Analysis Furin - antagonists & inhibitors Furin - chemistry Histidine - chemistry Humans Inhibitory Concentration 50 Ions Kinetics Mercury - chemistry Models, Chemical Proprotein Convertases - metabolism Pyridines - pharmacology Saccharomyces cerevisiae Proteins - metabolism Time Factors Zinc - chemistry Zinc - pharmacology Zinc Compounds - pharmacology
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