Localization of the Serine Protease-binding Sites in the Collagen-like Domain of Mannose-binding Protein

Mutations in the collagen-like domain of serum mannose-binding protein (MBP) interfere with the ability of the protein to initiate complement fixation through the MBP-associated serine proteases (MASPs). The resulting deficiency in the innate immune response leads to susceptibility to infections. St...

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Veröffentlicht in:	The Journal of biological chemistry 2004-04, Vol.279 (14), p.14065-14073
Hauptverfasser:	Wallis, Russell, Shaw, Jonathan M., Uitdehaag, Joost, Chen, Ce-Belle, Torgersen, Dawn, Drickamer, Kurt
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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