Multiple Mechanisms for Wnt11-mediated Repression of the Canonical Wnt Signaling Pathway

The effect of a noncanonical Wnt, Wnt11, on canonical Wnt signaling stimulated by Wnt1 and activated forms of LRP5 (low density lipoprotein receptor-related protein-5), Dishevelled1 (Dvl1), and Î²-catenin was examined in NIH3T3 cells and P19 embryonic carcinoma cells. Wnt11 repressed Wnt1-mediated a...

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Veröffentlicht in:	The Journal of biological chemistry 2004-06, Vol.279 (23), p.24659-24665
Hauptverfasser:	Maye, Peter, Zheng, Jie, Li, Lin, Wu, Dianqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin Blotting, Western Calcium - metabolism Cell Line Cell Line, Tumor Coculture Techniques Cytoskeletal Proteins - metabolism Dose-Response Relationship, Drug Genes, Reporter Glycoproteins - metabolism Ligands Mice NIH 3T3 Cells Proto-Oncogene Proteins - metabolism Receptors, G-Protein-Coupled - metabolism RNA, Small Interfering - metabolism Signal Transduction Trans-Activators - metabolism Transfection Wnt Proteins
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