Linkage of Interactions in Sickle Hemoglobin Fiber Assembly

The AB and GH regions of the α-chain are located in spatial proximity and contain a cluster of intermolecular contact residues of the sickle hemoglobin (HbS) fiber. We have examined the role of dynamics of AB/GH region on HbS polymerization through simultaneous replacement of non-contact Ala 19 and...

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Veröffentlicht in:	The Journal of biological chemistry 2004-05, Vol.279 (19), p.20018-20027
Hauptverfasser:	Sudha, Rajamani, Anantharaman, Lavanya, Sivaram, Mylavarapu V.S., Mirsamadi, Neda, Choudhury, Devapriya, Lohiya, Nirmal K., Gupta, Rasik B., Roy, Rajendra P.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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