Heterodimerization of Type A and B Cholecystokinin Receptors Enhance Signaling and Promote Cell Growth

Dimerization of several G protein-coupled receptors has recently been described, but little is known about its clinical and functional relevance. Cholecystokinin (CCK) and gastrin are structurally related gastrointestinal and neuronal peptides whose functions are mediated by two structurally related...

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Veröffentlicht in:	The Journal of biological chemistry 2003-12, Vol.278 (52), p.52972-52979
Hauptverfasser:	Cheng, Zhi-Jie, Harikumar, Kaleeckal G., Holicky, Eileen L., Miller, Laurence J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Division CHO Cells Chromatography, High Pressure Liquid COS Cells Cricetinae Dimerization DNA, Complementary - metabolism Dose-Response Relationship, Drug Fluorescent Dyes - pharmacology Humans Kinetics Ligands Microscopy, Confocal Protein Binding Receptor, Cholecystokinin A - chemistry Receptor, Cholecystokinin B - chemistry Signal Transduction Time Factors
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