The Death Effector Domain Protein PEA-15 Prevents Nuclear Entry of ERK2 by Inhibiting Required Interactions

ERK2 nuclear-cytoplasmic distribution is regulated in response to hormones and cellular state without the requirement for karyopherin-mediated nuclear import. One proposed mechanism for the movement of ERK2 into the nucleus is through a direct interaction between ERK2 and nucleoporins present in the...

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Veröffentlicht in:	The Journal of biological chemistry 2004-03, Vol.279 (13), p.12840-12847
Hauptverfasser:	Whitehurst, Angelique W., Robinson, Fred L., Moore, Mary Shannon, Cobb, Melanie H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Apoptosis Regulatory Proteins Cell Nucleus - metabolism Cytoplasm - metabolism Dose-Response Relationship, Drug Fungal Proteins - metabolism Green Fluorescent Proteins Luminescent Proteins - metabolism MAP Kinase Kinase 1 MAP Kinase Signaling System Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase Kinases - metabolism Models, Molecular Mutation Nuclear Pore Complex Proteins - chemistry Nuclear Pore Complex Proteins - metabolism Phosphoproteins - chemistry Protein Binding Protein Structure, Tertiary Rats Recombinant Proteins - chemistry Two-Hybrid System Techniques
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