Identification of Selective Inhibitors of NAD+-dependent Deacetylases Using Phenotypic Screens in Yeast

Sir2 and Hst1 are NAD+-dependent deacetylases involved in transcriptional repression in yeast. The two enzymes are highly homologous yet have different sensitivity to the small-molecule inhibitor splitomicin (compound 1) (Bedalov, A., Gatbonton, T., Irvine, W. P., Gottschling, D. E., and Simon, J. A...

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Veröffentlicht in:	The Journal of biological chemistry 2003-12, Vol.278 (52), p.52773-52782
Hauptverfasser:	Hirao, Maki, Posakony, Jeffrey, Nelson, Melisa, Hruby, Henning, Jung, Manfred, Simon, Julian A., Bedalov, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence beta-Galactosidase - metabolism Blotting, Northern Dose-Response Relationship, Drug Drug Resistance, Fungal Enzyme Inhibitors - pharmacology Genes, Fungal Genes, Reporter Genome, Fungal Histone Deacetylase Inhibitors Histone Deacetylases - chemistry Models, Chemical Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed NAD - metabolism Naphthalenes - pharmacology Oligonucleotide Array Sequence Analysis Phenotype Plasmids - metabolism Pyrones - pharmacology Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - chemistry Sequence Homology, Amino Acid Silent Information Regulator Proteins, Saccharomyces cerevisiae - antagonists & inhibitors Silent Information Regulator Proteins, Saccharomyces cerevisiae - chemistry Sirtuin 2 Sirtuins - antagonists & inhibitors Sirtuins - chemistry Telomere - ultrastructure
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