GIT1 Mediates Src-dependent Activation of Phospholipase Cγ by Angiotensin II and Epidermal Growth Factor

Critical events for vasoconstrictor and growth factor signal transduction include stimulation of phospholipase Cγ (PLCγ) and elevation of intracellular calcium. c-Src has been proposed as a common mediator for these signals activated by both G protein-coupled receptors (GPCRs) and tyrosine kinase-co...

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Veröffentlicht in:The Journal of biological chemistry 2003-12, Vol.278 (50), p.49936-49944
Hauptverfasser: Haendeler, Judith, Yin, Guoyong, Hojo, Yukihiro, Saito, Yuji, Melaragno, Matthew, Yan, Chen, Sharma, Virendra K., Heller, Manfred, Aebersold, Ruedi, Berk, Bradford C.
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Sprache:eng
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