Separate Roles for the Golgi Apparatus and Lysosomes in the Sequestration of Drugs in the Multidrug-resistant Human Leukemic Cell Line HL-60

The sequestration of drugs away from cellular target sites into cytoplasmic organelles of multidrug-resistant (MDR) cancer cells has been recently shown to be a cause for ineffective drug therapy. This process is poorly understood despite the fact that it has been observed in a large number of MDR c...

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Veröffentlicht in:	The Journal of biological chemistry 2003-12, Vol.278 (50), p.50234-50239
Hauptverfasser:	Gong, Yuping, Duvvuri, Muralikrishna, Krise, Jeffrey P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Antineoplastic Agents - pharmacology Biological Transport Cell Line Cell Membrane - metabolism Chemokines, CC - metabolism Coloring Agents - pharmacology Daunorubicin - metabolism Daunorubicin - pharmacology Drug Resistance, Neoplasm Golgi Apparatus - metabolism Golgi Apparatus - physiology HL-60 Cells Humans Hydrogen-Ion Concentration Inhibitory Concentration 50 Lysosomes - metabolism Lysosomes - physiology Microscopy, Fluorescence Phenotype Rhodamines - pharmacology
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