Oxidative Degradation of Cardiotoxic Anticancer Anthracyclines to Phthalic Acids

We show that the pseudoperoxidase activity of ferrylmyoglobin (MbIV) promotes oxidative degradation of doxorubicin (DOX), an anticancer anthracycline known to induce severe cardiotoxicity. MbIV, formed in vitro by reacting horse heart MbIII with H2O2, caused disappearance of the spectrum of DOX at 4...

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Veröffentlicht in:	The Journal of biological chemistry 2004-02, Vol.279 (7), p.5088-5099
Hauptverfasser:	Cartoni, Antonella, Menna, Pierantonio, Salvatorelli, Emanuela, Braghiroli, Daniela, Giampietro, Rossella, Animati, Fabio, Urbani, Andrea, Del Boccio, Piero, Minotti, Giorgio
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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