Roles of Low Specificity and Cofactor Interaction Sites on Thrombin during Factor XIII Activation

Factor XIII is activated by thrombin, and this reaction is enhanced by the presence of fibrin(ogen). Using a substrate-based screening assay for factor XIII activity complemented by kinetic analysis of activation peptide cleavage, we show by using thrombin mutants of surface-exposed residues that Ar...

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Veröffentlicht in:	The Journal of biological chemistry 2003-08, Vol.278 (34), p.32020-32026
Hauptverfasser:	Philippou, Helen, Rance, James, Myles, Timothy, Hall, Scott W., Ariens, Robert A., Grant, Peter J., Leung, Lawrence, Lane, David A.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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