Photoaffinity Labeling Demonstrates Physical Contact between Vasoactive Intestinal Peptide and the N-terminal Ectodomain of the Human VPAC1 Receptor

Vasoactive intestinal peptide (VIP) is a prominent neuropeptide whose actions are mediated by VPAC receptors belonging to class II G protein-coupled receptors. To identify contact sites between VIP and its VPAC1 receptor, an analog of VIP substituted with a photoreactive para-benzoyl-l-Phe (Bpa) at...

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Veröffentlicht in:	The Journal of biological chemistry 2003-09, Vol.278 (38), p.36531-36536
Hauptverfasser:	Tan, Yossan-Var, Couvineau, Alain, Van Rampelbergh, Jean, Laburthe, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding, Competitive CHO Cells Cricetinae Cyanogen Bromide - pharmacology Electrophoresis, Polyacrylamide Gel Glycosylation Humans Kinetics Ligands Light Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Mutation Peptides - chemistry Photoaffinity Labels - pharmacology Protein Binding Protein Structure, Tertiary Receptors, Vasoactive Intestinal Peptide - chemistry Receptors, Vasoactive Intestinal Polypeptide, Type I Recombinant Fusion Proteins - metabolism Transfection Vasoactive Intestinal Peptide - chemistry
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