Dwarfism and Low Insulin-like Growth Factor-1 Due to Dopamine Depletion in Pts–/– Mice Rescued by Feeding Neurotransmitter Precursors and H4-biopterin

The tetrahydrobiopterin (BH4) cofactor is essential for the biosynthesis of catecholamines and serotonin and for nitric-oxide synthase (NOS). Alterations in BH4 metabolism are observed in various neurological and psychiatric diseases, and mutations in one of the human metabolic genes causes hyperphe...

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Veröffentlicht in:	The Journal of biological chemistry 2003-07, Vol.278 (30), p.28303-28311
Hauptverfasser:	Elzaouk, Lina, Leimbacher, Walter, Turri, Matteo, Ledermann, Birgit, Bürki, Kurt, Blau, Nenad, Thöny, Beat
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptophan - pharmacology Animals Biopterins - analogs & derivatives Biopterins - chemistry Biopterins - metabolism Body Weight Cell Division Dopamine - metabolism Dwarfism - genetics Gene Deletion Genetic Vectors Genotype Heterozygote Homozygote Insulin-Like Growth Factor I - metabolism Kinetics Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neurotransmitter Agents Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Phenotype Phosphorus-Oxygen Lyases - genetics Phosphorus-Oxygen Lyases - metabolism Phosphorus-Oxygen Lyases - physiology Polymerase Chain Reaction Thyroxine - blood Time Factors
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