Vitamin K2 Regulation of Bone Homeostasis Is Mediated by the Steroid and Xenobiotic Receptor SXR

Vitamin K2 is a critical nutrient required for blood clotting that also plays an important role in bone formation. Vitamin K2 supplementation up-regulates the expression of bone markers, increases bone density in vivo, and is used clinically in the management of osteoporosis. The mechanism of vitami...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2003-11, Vol.278 (45), p.43919-43927
Hauptverfasser:	Tabb, Michelle M., Sun, Aixu, Zhou, Changcheng, Grün, Felix, Errandi, Jody, Romero, Kimberly, Pham, Hang, Inoue, Satoshi, Mallick, Shyamali, Lin, Min, Forman, Barry M., Blumberg, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - analysis Alkaline Phosphatase - genetics Animals Biomarkers - analysis Bone and Bones - metabolism Bone Density - drug effects Bridged Bicyclo Compounds COS Cells Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics Gene Expression - drug effects Glycoproteins - genetics HeLa Cells Homeostasis - drug effects Humans Mice Mice, Knockout Osteoblasts - chemistry Osteocalcin - genetics Osteopontin Osteoprotegerin Osteosarcoma - chemistry Phloroglucinol - analogs & derivatives Pregnane X Receptor Receptors, Cytoplasmic and Nuclear - genetics Receptors, Steroid - deficiency Receptors, Steroid - genetics Receptors, Steroid - physiology Receptors, Tumor Necrosis Factor Recombinant Proteins Reverse Transcriptase Polymerase Chain Reaction Rifampin - pharmacology RNA, Messenger - analysis Sialoglycoproteins - genetics Terpenes - pharmacology Transfection Tumor Cells, Cultured Vitamin K 2 - metabolism Vitamin K 2 - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!