Identification of a Negatively Charged Peptide Motif within the Catalytic Domain of Progelatinases That Mediates Binding to Leukocyte β2 Integrins

The αMβ2 integrin of leukocytes can bind a variety of ligands. We screened phage display libraries to isolate peptides that bind to the αM I domain, the principal ligand binding site of the integrin. Only one peptide motif, (D/E)(D/E)(G/L)W, was obtained with this approach despite the known ligand b...

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Veröffentlicht in:	The Journal of biological chemistry 2003-09, Vol.278 (36), p.34674-34684
Hauptverfasser:	Stefanidakis, Michael, Björklund, Mikael, Ihanus, Eveliina, Gahmberg, Carl G., Koivunen, Erkki
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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