Acidification of the Malaria Parasite's Digestive Vacuole by a H+-ATPase and a H+-pyrophosphatase

As it grows within the human erythrocyte, the malaria parasite, Plasmodium falciparum , ingests the erythrocyte cytosol, depositing it via an endocytotic feeding mechanism in the “digestive vacuole,” a specialized acidic organelle. The digestive vacuole is the site of hemoglobin degradation, the...

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Veröffentlicht in:	The Journal of biological chemistry 2003-02, Vol.278 (8), p.5605-5612
Hauptverfasser:	Saliba, Kevin J, Allen, Richard J W, Zissis, Stephanie, Bray, Patrick G, Ward, Stephen A, Kirk, Kiaran
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Digestion Digestive System - enzymology Erythrocytes - parasitology Humans Hydrogen-Ion Concentration Inorganic Pyrophosphatase Kinetics Malaria, Falciparum - parasitology Plasmodium falciparum - enzymology Pyrophosphatases - metabolism Vacuolar Proton-Translocating ATPases - metabolism
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