Up-regulation and Polarized Expression of the Sodium-Ascorbic Acid Transporter SVCT1 in Post-confluent Differentiated CaCo-2 Cells

Human cells acquire vitamin C using two different transporter systems, the sodium-ascorbic acid co-transporters with specificity for ascorbic acid, and the facilitative glucose transporters with specificity for dehydroascorbic acid. There is no information on the mechanism of vitamin C transport acr...

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Veröffentlicht in:	The Journal of biological chemistry 2003-03, Vol.278 (11), p.9035-9041
Hauptverfasser:	Nancy P. MaulÃ©n, Esther A. HenrÄ±Ìquez, Sybille Kempe, Juan G. CÃ¡rcamo, Alexandra Schmid-Kotsas, Max Bachem, Adolph GrÃ¼nert, Marcelo E. Bustamante, Francisco Nualart, Juan Carlos Vera
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbic Acid - metabolism Ascorbic Acid - pharmacology Biological Transport Cell Differentiation Cells, Cultured Dehydroascorbic Acid - metabolism Deoxyglucose - metabolism DNA - metabolism Dose-Response Relationship, Drug Glucose Transporter Type 1 Glucose Transporter Type 5 Hexoses - metabolism Humans Kinetics Monosaccharide Transport Proteins - metabolism Organic Anion Transporters, Sodium-Dependent - biosynthesis Organic Anion Transporters, Sodium-Dependent - metabolism Protein Conformation Protein Transport Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Sodium-Coupled Vitamin C Transporters Symporters - biosynthesis Symporters - metabolism Time Factors Tumor Cells, Cultured Up-Regulation
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