The RhoA-binding protein, Rhophilin-2, Regulates Actin Cytoskeleton Organization

The Rho GTPases regulate the actin cytoskeleton through interactions with various downstream effector molecules. Here we have identified a ubiquitously expressed human RhoA-binding protein, designated Rhophilin-2. Rhophilin-2 shows 40% amino acid similarity to human Rhophilin-1 and contains an N-ter...

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Veröffentlicht in:	The Journal of biological chemistry 2002-11, Vol.277 (46), p.43924-43932
Hauptverfasser:	Peck, Jeremy W, Oberst, Michael, Bouker, Kerrie B, Bowden, Emma, Burbelo, Peter D
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Actins - metabolism Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Base Sequence Blotting, Northern Carrier Proteins - chemistry Carrier Proteins - metabolism Carrier Proteins - physiology Cloning, Molecular Cytoskeleton - metabolism DNA, Complementary - metabolism Gene Library Genes, Reporter Genetic Vectors Glutathione Transferase - metabolism HeLa Cells Humans Luciferases - metabolism Mice Molecular Sequence Data Protein Binding Protein Isoforms Protein Structure, Tertiary Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Recombinant Fusion Proteins - metabolism rhoA GTP-Binding Protein - metabolism Sequence Homology, Amino Acid Signal Transduction Tissue Distribution Transfection
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