Associations of B- and C-Raf with Cholesterol, Phosphatidylserine, and Lipid Second Messengers

The serine/threonine kinase C-Raf is a key mediator in cellular signaling. Translocation of Raf to membranes has been proposed to be facilitated by Ras proteins in their GTP-bound state. In this study we provide evidence that both purified B- and C-Raf kinases possess lipophilic properties and assoc...

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Veröffentlicht in:	The Journal of biological chemistry 2002-07, Vol.277 (27), p.24090-24102
Hauptverfasser:	Hekman, Mirko, Hamm, Heike, Villar, Ana V., Bader, Benjamin, Kuhlmann, Jürgen, Nickel, Joachim, Rapp, Ulf R.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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