Insights into Brain Glycogen Metabolism

Brain glycogen metabolism plays a critical role in major brain functions such as learning or memory consolidation. However, alteration of glycogen metabolism and glycogen accumulation in the brain contributes to neurodegeneration as observed in Lafora disease. Glycogen phosphorylase (GP), a key enzy...

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Veröffentlicht in:	The Journal of biological chemistry 2016-08, Vol.291 (35), p.18072-18083
Hauptverfasser:	Mathieu, Cécile, de la Sierra-Gallay, Ines Li, Duval, Romain, Xu, Ximing, Cocaign, Angélique, Léger, Thibaut, Woffendin, Gary, Camadro, Jean-Michel, Etchebest, Catherine, Haouz, Ahmed, Dupret, Jean-Marie, Rodrigues-Lima, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	allosteric regulation brain functions brain metabolism crystal structure energy metabolism glycogen glycogen metabolism Lafora disease (Lafora progressive myoclonic epilepsy, MELF)
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