Cyclic GMP Kinase II (cGKII) Inhibits NHE3 by Altering Its Trafficking and Phosphorylating NHE3 at Three Required Sites

The epithelial brush-border Na+/H+ exchanger NHE3 is acutely inhibited by cGKII/cGMP, but how cGKII inhibits NHE3 is unknown. This study tested the hypothesis that cGMP inhibits NHE3 by phosphorylating it and altering its membrane trafficking. Studies were carried out in PS120/NHERF2 and in Caco-2/B...

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Veröffentlicht in:	The Journal of biological chemistry 2015-01, Vol.290 (4), p.1952-1965
Hauptverfasser:	Chen, Tiane, Kocinsky, Hetal S., Cha, Boyoung, Murtazina, Rakhilya, Yang, Jianbo, Tse, C. Ming, Singh, Varsha, Cole, Robert, Aronson, Peter S., de Jonge, Hugo, Sarker, Rafiquel, Donowitz, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclic GMP (cGMP) Epithelial Cell Intestine Phosphorylation Sodium-proton Exchange Trafficking
Online-Zugang:	Volltext
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