Alternative C-Terminal Helix Orientation Alters Chemokine Function

Chemokines, a subfamily of cytokines, are small, secreted proteins that mediate a variety of biological processes. Various chemokines adopt remarkable conserved tertiary structure comprising an anti-parallel β-sheet core domain followed by a C-terminal helix that packs onto the β-sheet. The conserve...

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Veröffentlicht in:	The Journal of biological chemistry 2013-05, Vol.288 (19), p.13522-13533
Hauptverfasser:	Kuo, Je-Hung, Chen, Ya-Ping, Liu, Jai-Shin, Dubrac, Alexandre, Quemener, Cathy, Prats, Hervé, Bikfalvi, Andreas, Wu, Wen-guey, Sue, Shih-Che
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Chemokines CXCL4L1 Heparin Platelet Factor 4 Platelets X-ray Crystallography
Online-Zugang:	Volltext
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