Fetal Cardiac Troponin Isoforms Rescue the Increased Ca2+ Sensitivity Produced by a Novel Double Deletion in Cardiac Troponin T Linked to Restrictive Cardiomyopathy

A novel double deletion in cardiac troponin T (cTnT) of two highly conserved amino acids (Asn-100 and Glu-101) was found in a restrictive cardiomyopathic (RCM) pediatric patient. Clinical evaluation revealed the presence of left atrial enlargement and marked left ventricle diastolic dysfunction. The...

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Veröffentlicht in:	The Journal of biological chemistry 2011-06, Vol.286 (23), p.20901-20912
Hauptverfasser:	Pinto, Jose Renato, Yang, Shi Wei, Hitz, Marc-Phillip, Parvatiyar, Michelle S., Jones, Michelle A., Liang, Jingsheng, Kokta, Victor, Talajic, Mario, Tremblay, Nicolas, Jaeggi, Michelle, Andelfinger, Gregor, Potter, James D.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATPases Calcium-binding Proteins Cardiac Hypertrophy Cardiac Muscle Mutant Protein-Protein Interactions Restrictive Cardiomyopathy Skinned Fibers Troponin
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