The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells

Cyclin-dependent kinase inhibitor (CDKN1A), often referred to as p21(Waf1/Cip1) (p21), is induced by a variety of environmental stresses. Transcription factor ELK-1 is a member of the ETS oncogene superfamily. Here, we show that ELK-1 directly trans-activates the p21 gene, independently of p53 and E...

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Veröffentlicht in:	The Journal of biological chemistry 2011-07, Vol.286 (30), p.26860-26872
Hauptverfasser:	Shin, Soon Young, Kim, Chang Gun, Lim, Yoongho, Lee, Young Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Arsenites - pharmacology bcl-2-Associated X Protein - biosynthesis bcl-2-Associated X Protein - genetics Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 - genetics Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology ets-Domain Protein Elk-1 - genetics ets-Domain Protein Elk-1 - metabolism Gene Expression Regulation - drug effects Humans Keratinocytes MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Response Elements RNA, Messenger - biosynthesis RNA, Messenger - genetics Sodium Compounds - pharmacology
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